Playing with the term artificiality through two of its distinct interpretations; synthetic biology and the humanly contrived. Scientific knowledge and achievements are growing exponentially, with bio–genetic limbs and pacemakers currently available and genetically engineered organs lying squarely within the realm of future possibility. The social concept of artificial, however, remains contradictory to the outputs of scientific inquiry and revolves around a certain understanding of an exaggerated aesthetics that is often considered cheap, contrived and synthetic. Both the scientific and social areas as they are progressively refined, perfected and arguably merged, raise philosophical questions about the term artificial itself. These questions include, but are by no means limited to, whether or not organic matter that has been altered but not created by a human hand should be considered man-made or natural; whether a manufactured material is to be considered synthetic although it occurs in nature, and whether it is necessary to make a distinction between natural and synthetic in the first place.